Binghamton University Home     |     B.U. Psychology Department
LISA M. SAVAGE
Associate Professor of Psychology
Ph.D., University of Minnesota
Post-doctoral training: VA Medical Center, San Diego
Area: Behavioral Neuroscience
E-mail: lsavage@binghamton.edu
Phone: 607-777-4383
Office: Science IV, Room 253

Curriculum vita

Professional Activities: Fellow of the American Psychological Association, Society for Neuroscience, and the Center for Developmental Psychobiology

Research Interests: Animal models of memory disorders, neurobiology of memory and reward

Research Description: One of the main goals of psychology is to understand how organisms learn and remember information. The study of how memories are organized in the brain has advanced immensely in the last three decades. The use of animal models has enhanced the understanding of the biological processes involved in cognition, memory and emotion. There exists a wide range of methodologies to access etiologic and symptomatic factors of memory disturbances. Using drugs, diet, neurotoxins, and aged rodents, I attempt to model human amnesia (i.e., Wernicke-Korsakoff's disease, Alcohol-Induced Dementia, Alzheimer's disease). My research is a combination of both micro- and macro-level analyses. Behavior of the whole organism is assessed before and after brain damage, and the extent of brain pathology is correlated with behavioral impairment. I am particularly interested in the interactions between specific types of learning and memory problems and specific neurochemical and neuroanatomical abnormalities. In a broad sense, this type of research contributes to the understanding of brain-behavior relationships. The goal of my research is to gain a better understanding of the neurobiology of memory and the development of psychological and pharmacological therapeutics for the treatment of memory disorders.

Philosophy of Graduate Training: Students should be excited about, as well as devoted to, the topic they chose as their graduate study. This interest must span both course work and research. At Binghamton University our programs offer a unique balance between classroom and laboratory experiences. As a faculty member, I view my role in graduate education as a "colleague" to students. My aim is to advise students in theory as well as the design of sound research projects that will answer interesting questions about brain-behavioral relationships.

Selected Publications: (* indicates student co-author)

1. Chang, Q, Savage, L.M., & Gold, P.E. (2006). Microdialysis measures of functional increases and brain regional differences in ACh release: A requirement for acetylcholinesterase inhibitors in the perfusate. Journal of Neurochemistry. 97, 697-706.

2. Savage, L.M ., Roland, J.J.*, Klintsova A. (2007). Selective septohippocampal but not forebrain amygdalar cholinergic dysfunction in diencephalic amnesia. Brain Research, 1139, 210-219. (Download PDF)

3. Ramirez, D.* & Savage, L.M . (2007). Differential Involvement of the basolateral amygdala, orbitofrontal cortex, and nucleus accumbens core in the acquisition and use of reward expectancies. Behavioral Neuroscience, 121, 896-906. (Download PDF)

4. Savage, L.M , Koch, A.* & Ramirez, D.* (2007). Amygdala inactivation by muscimol, but not ERK/MAPK inhibition, impairs the use of reward expectancies during short-term memory. European Journal of Neuroscience, 26 , 3645-3651. (Download PDF)

5. Vetreno, R. * Anzalone, S. *, & Savage L.M . (2008). Impaired, spared and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands. Neurobiology of Learning and Memory, 90, 237-244.

To print this bio, click here to open in a full window and use your browser's PRINT function.